Double blow for Bafana
Khune is down with a chest infection while Keet is suffering from a knee injury.
Head coach Stuart Baxter has called up Reyaad Pieterse of Supersport United as well as Wayne Sandilands of Orlando Pirates as replacements.
South Africa faces Cape Verde on Friday, 1 September 2017 at the Estadio Nacional Stadium in Cape Verde.
Kickoff is at 17h30 local time (20h30 SA time).
The return leg will be played on Tuesday, 5 September at the Moses Mabhida Stadium in Durban.
Kickoff is at 19h00.
Bafana Bafana assemble for camp on Sunday, 27 August 2017 in Johannesburg, and expected to travel to Cape Verde on Tuesday, 29 August.
Updated Bafana Bafana squad:
Updated BAFANA BAFANA SQUAD TO FACE CAPE VERDE GOALKEEPERS:1.Riyaad PIETERSESupersport United FC (SA)2.Wayne SANDILANDSOrlando Pirates FC (SA)3.Ronwen WILLIAMSSupersport United FC (SA) DEFENDERS:4.Ramahlwe MPHAHLELEKaizer Chiefs FC (SA)5.Rivaldo COETZEEAjax Cape Town FC (SA)6.Thulani HLATSHWAYO (C)Bidvest Wits FC (SA)7.Erick MATHOHOKaizer Chiefs FC (SA)8.Morgan GOULDSupersport United (SA)9.Abbubaker MOBARAOrlando Pirates FC (SA)10.Tebogo LANGERMANMamelodi Sundowns FC11.Sifiso HLANTIBidvest Wits FC (SA) MIDFIELDERS:12.Hlompho KEKANAMamelodi Sundowns FC (SA)13.Keagan DOLLYMontpellier (France)14.Andle JALIKV Oostende FC (SA)15.Kamohelo MOKOTJOBrentford FC (Netherlands)16.Dean FURMANSupersport United FC (SA)17.Themba ZWANEMamelodi Sundowns FC (SA)18.Bongani ZUNGUVitoria Guimares (Portugal)19.Thulani SEREROSBV Vitesse (Holland) STRIKERS20.Daylon KLAASENBidvest Wits FC (SA)21.Percy TAUMamelodi Sundowns FC (SA)22.Lebohang MANYAMACape Town City FC (SA)23.Tokelo RANTIEGenclerbirligi FC (Turkey)24.Bradley GROBLERSupersport United FC (SA)25.Kermit ERASMUSRennes (France)