When they got the python back to the clinic, they discovered the almost 4m long snake was in need of some TLC.
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SPCA manager Barbara Patrick says the snake was very dehydrated.
"On examination of its mouth, we also found a tooth had come out and there was a slight infection in that area," she said.
Patrick says after giving the python a clean bill of health, they arranged to release him back into the wild.
You can find a selection of photos posted by the Kloof and Highway SPCA before the python's release below:
Bongani and Mags chat with Distruction Boyz after a trailblazing journey...East Coast Drive with Bongani and Mags 1 day, 21 hours ago
Kendal McGlashan said "yes" to her boyfriend in a romantic setting that ...Jane Linley-Thomas 2 days, 1 hour ago