Emergency services say they arrived at the scene and found that the car had sustained major structural damage upon impact.
NOW READ: Six killed, dozens hurt in KZN bus crashThe driver of the car was still trapped inside the vehicle. He was assessed and found to be in a critical condition.
Midlands EMS says Advanced Life Support paramedics treated him while rescuers used the jaws of life and other hydraulic equipment to cut him free from the wreckage.
"One he was freed from the vehicle, his condition deteriorated and CPR was initiated," said spokesperson Derrick Banks.
"Medics did all they could for him, but he unfortunately succumbed to the severe injuries he sustained."
ALSO READ: Twelve arrested at Clairwood chop shopBanks says the driver of the truck was not hurt.
The exact cause of the crash is unknown at this stage. Authorities were on scene and will be investigating further.
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