It's understood the vehicles collided along Sugar Mill Road just before 7.30am.
No passengers from the bus were hurt in the crash.
Netcare911 says 2 occupants of the bakkie sustained minor injuries - while a third was seriously hurt.
Mewanwhile, four people have been hurt in a side-impact crash on Hillhead Drive in Mount Edgecombe.
Paramedics say one person was seriously hurt while the others sustained minor injuries.
(Photo via Netcare 911 shows the side-impact crash in Mount Edgecombe)
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